Synthesis of D-glycero-D-gulo-heptose, D-glycero-D-ido-heptose, and 2-deoxy-D-gluco-heptose from D-glucose
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چکیده
منابع مشابه
Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis.
The core oligosaccharide component of the lipopolysaccharide can be subdivided into inner and outer core regions. In Escherichia coli, the inner core consists of two 3-deoxy-d-manno-octulosonic acid and three glycero-manno-heptose residues. The HldE protein participates in the biosynthesis of ADP-glycero-manno-heptose precursors used in the assembly of the inner core. HldE comprises two functio...
متن کاملSynthesis of polyhydroxy amino acids based on D- and L-alanine from D-glycero-D-gulo-heptono-1,4-lactone.
2-Amino-2,3-dideoxy-D-manno-heptonic acid (7) has been synthesized from 2,5,6,7-tetra-O-acetyl-3-deoxy-D-gluco-heptono-1,4-lactone (1), which was readily prepared from D-glycero-D-gulo-heptono-1,4-lactone. O-Deacetylation of 1 followed by treatment with 13:1 (v/v) 2,2-dimethoxypropane/acetone in the presence of p-toluenesulfonic acid gave methyl 3-deoxy-4,5:6,7-di-O-isopropylidene-D-gluco-hepto...
متن کاملSynthesis and quantitative evaluation of Glycero-D-manno-heptose binding to concanavalin A by fluorous-tag assistance.
tion was reported earlier in the first demonstration of a microarray fabrication strategy based on noncovalent fluorous interactions. Mannose and other monosaccharides tagged by single C8F17 chains were noncovalently immobilized to fluorocarbon-coated glass slide surfaces and shown to tolerate conditions necessary for identifying binding partners such as conA. More recently, this fluorous-based...
متن کامل1,5-Anhydro-3,6-di-O-benzyl-2-deoxy-1,2-C-dichloromethylene-d-glycero-d-gulo-hexitol
In the title compound, C(21)H(22)Cl(2)O(4), the pyranosyl ring adopts a twist-boat conformation with the O-benzyl groups in equatorial positions. In the crystal, O-H⋯O hydrogen bonding results in infinite chains of mol-ecules along [100]. The structure is further consolidated by weak C-H⋯O, C-H⋯Cl and C-H⋯π inter-actions. The absolute structure was determined.
متن کاملgmhX, a novel gene required for the incorporation of L-glycero-D-manno-heptose into lipooligosaccharide in Neisseria meningitidis.
Lipooligosaccharide (LOS) is a critical virulence factor of Neisseria meningitidis. A Tn916 insertion mutant, designated 469, was found to exhibit a markedly truncated LOS of 2.9 kDa when compared by Tricine/SDS-PAGE to the parental LOS (4.6 kDa). Electrospray mass spectrometry analysis of 469 LOS revealed that it consisted of the deep rough, heptose-deficient structure, Kdo(2)-lipid A. Sequenc...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1969
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v69-459